SentinelOne vs Microsoft Defender for Endpoint

13 April 2022 | ITHQ Tech Team

SentinelOne and Microsoft Defender are both endpoint protection solutions designed to help organizations secure their networks and devices against cyber threats. Both products offer features such as real-time protection, threat detection and response, and malware removal ... but which one is best for you?

One key difference between the two products is that SentinelOne offers an extended detection and response (XDR) capability, which is a more comprehensive approach to threat detection and response that involves collecting and analyzing data from a wider range of sources, such as endpoints, networks, and the cloud. Microsoft Defender, on the other hand, is primarily focused on endpoint protection.

SentinelOne is a third-party security solution, while Microsoft Defender is a built-in security feature

of Windows 10. This means that Microsoft Defender is already installed and configured on all Windows 10 devices, while SentinelOne needs to be installed and configured separately.

In terms of pricing, Microsoft Defender is generally considered to be more affordable than SentinelOne, as it is included with Windows 10 at no additional cost. SentinelOne, on the other hand, is a paid solution and pricing can vary depending on the specific features and number of devices covered.

Overall, both SentinelOne and Microsoft Defender can be effective solutions for protecting against cyber threats, but SentinelOne's XDR capabilities and focus on comprehensive threat detection and response may make it a better fit for organizations with more complex security needs. It is important to carefully evaluate the specific needs and requirements of your organization before deciding which endpoint protection solution is right for you.

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Endpoint Protection: Key considerations

  • Is it easy to deploy and manage?
  • Is it dependent on cloud command and control for detection and response?
  • How effective has it been against zero-day attacks?
  • Do you have feature parity across Windows, Mac and Linux?
  • How does it perform in real world test scenarios?
  • What do other customers say about it?


Comparison of Business Benefits and Features

  Microsoft Defender for Endpoint SentinelOne logo
Business Benefits
Autonomous prevention, detection, and recovery from threats in real-time. Cloud dependent
Fast Recovery
Partial (AIR on E5)
Yes - Can be automated or 1-click
OS freedom (Windows / Mac / Linux feature parity)
Yes Yes
Fewer alerts with more context
Incident based
AI-powered prevention, detection, response, and threat hunting. Explorer - manual storylines Yes
API integration
Yes Yes
Scalability Yes Yes - Support for containers and serverless workloads, especially Kubernetes dynamic workloads.
Higher accuracy across entire attack surface. Yes - attack surface reduction enhancements. Yes - Consistent identification of tactics and techniques in the MITRE Phase 2 evaluations.
Centralised Visibility Yes Yes - full storyline.
Automation & Control Yes Yes - Automated mitigation options via the Storyline Active Response Capability.
Data analytics Yes No - SentinelOne does not have its own network security sources to add.

Collection and reporting of; inventory, config and policy management of endpoint devices.

Yes - e.g. threat intelligence reporting. Yes

Mobile Threat Defence

Yes Yes

Ease of deployment

No - no on-premise console.

Yes - Excellent timeliness and quality of customer support.


AI across user endpoints, containers, cloud workloads, and IoT devices.

No - dropped support for E-o-L systems.
Yes - New IoT discovery and protection capabilities in its Ranger product.
Static & Behavioural AI
Exploit protection Heuristics Yes + context
Lateral movement Heuristics Yes + context
Remediation Automated
Rollback No
Integrated threat feeds Yes
Remote shell No
Device control Yes - Device Discovery
Yes - Device discovery via Ranger.
Firewall control Yes
Bluetooth control Yes Yes
Threat hunting
Yes - full storyline
Deep visibility Yes - Sandbox (deep analysis)
Event Correlation No
Execution Restriction Yes - EDR in block mode. Yes
Vulnerability scanning Yes - UEFI scanning. Yes - Priority list of vulnerable applications.
Security patching No Yes
Triage Yes - decision-making algorithms. Yes - Investigate in seconds with automated correlations and Storyline.
Disk Encryption No No - Missing add-on for fully featured DLP.


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Industry and Peer Reviews

Gartner Peer Insights

Microsoft Defender for Endpoint logo

SentinelOne logo




Gartner Magic Quadrant for Endpoint Protection Platforms May 2021





Independent Testing


Microsoft Defender for Endpoint


SentinelOne logo
Provided coverage across the attack chain stages


APT29 2020

Scored record results:

  • Least missed detections
  • Most high-quality detections
  • Most correlated detections
NSS labs Top ROI score and Recommended rating 2019
NOT CURRENTLY CERTIFIED VB100virus 99.8% block rate across Windows testing

Top Product for Windows

Only 1 false-positive


100% protection against zero-day malware attacks on Windows


In top 10 vendors

Recognized for the commitment to pushing the boundaries of autonomous technology — delivering innovation at scale and speed, and shaping the endpoint market.

 Above average UI launch time

Below average memory usage

Quickest file copy, move and delete time

Longest file compression/ decompression time


Performs better than several legacy AV products for the following:

  • Quickest boot time
  • Quickest install time
  • Smallest install size
  • Lowest CPU usage during scan


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All prices calculated at per endpoint per month, for comparison purposes.

Pricing is 'starting from' and based on list pricing. It can be subject to change, volume discounts etc.

Correct at February 2021


Contact us for accurate pricing based on your specific requirements

SentinelOne logo

 Minimum purchase - 5 endpoints - only through ITHQ

Payment can be billed monthly - only through ITHQ

To achieve these prices below, minimum purchase 100 endpoints, billed annually.

Quote always required for accurate pricing

Core Control Complete
$4.16 $4.90 $9.00
Includes full advanced EDR
All Core features plus device, firewall and bluetooth control
All Control features plus threat hunting and deep visibility


Microsoft Defender for Endpoint Logo

Minimum purchase - 100 endpoints

Payment always billed annually

Priced according to Microsoft

$22.00 per user per month

Can't be bought separately – requires Microsoft 365 Business Premium.

This means that to buy security from Microsoft, you have to effectively buy email, the office suite, Azure AD, Windows 10, Teams, OneDrive, Sharepoint, Bitlocker, SCCM and more.